Research

Clinical trials

Harmonized multinational trials running across the MELLOW Consortium network, from early recruitment through completed studies.

All Active Recruiting Completed Planned

MetabolicRecruiting

Metformin and Healthspan in Pre-Diabetic Adults

Evaluating whether early metformin intervention slows metabolic ageing markers in pre-diabetic adults aged 50-70.

CognitiveActive

Cognitive Resilience Following Combined Exercise-Nutrition Intervention

A 12-month combined intervention testing structured exercise plus targeted nutrition on cognitive resilience in adults 65+.

Cellular SenescenceRecruiting

Senolytic Combination Therapy in Early Frailty

Phase II study of combination senolytic therapy in adults with early markers of frailty and elevated cellular senescence burden.

CardiovascularActive

Time-Restricted Eating and Cardiometabolic Risk Markers

Randomized trial comparing time-restricted eating windows against standard dietary guidance on cardiometabolic risk markers.

MusculoskeletalCompleted

Resistance Training Dose-Response in Sarcopenia Prevention

Completed dose-response study identifying minimum effective resistance training volume for preserving muscle mass in adults 60+.

Sleep & CircadianPlanned

Circadian Light Exposure and Sleep Quality in Older Adults

Upcoming study on structured morning light exposure protocols and their effect on sleep quality and circadian alignment.

Skin & RegenerativeRecruiting

Topical NAD+ Precursors and Skin Biomarkers of Ageing

Evaluating topical NAD+ precursor formulations against placebo on validated biomarkers of skin ageing over 16 weeks.

MetabolicActive

Multinational Biological Age Clock Validation Study

The Consortium's flagship trial: validating a shared biological-age clock across seven countries and diverse ancestries: one protocol, one budget, one dataset.